Synthèse, caractérisation, évaluation biologique et étude théorique par DFT d’esters aminophosphonates et acides aminophosphoniques dérivés d’aminoalcool. / Aicha Yassa  

Public ISBD Titre : Synthèse, caractérisation, évaluation biologique et étude théorique par DFT d’esters aminophosphonates et acides aminophosphoniques dérivés d’aminoalcool. Type de document : texte imprimé Auteurs : Aicha Yassa ; Rahma May ; Abdelkader Hellal, Directeur de thèse Editeur : Sétif:UFA1 Année de publication : 2023 Importance : 1 vol. (82 f.) ISBN/ISSN/EAN : Synthèse, caractérisation, évaluation biologique e Langues : Français (fre) Catégories : Thèses & Mémoires:Chimie Mots-clés : α-aminophosphonate ester α-aminophosphonic acid Kabachnik-Fields reaction, DFT Antioxidant anti-inflammatory Résumé : This work was devoted for the synthesis of two series of α-aminophosphonates from two aliphatic amines with different carbon chains, to see the influence of chain length on the physicochemical properties, biological activities, as well as on the quantum properties of the obtained molecules. The aminophosphonate esters were synthesized, under microwave, via the Kabachnik-Fields reaction, from a primary amine, acetaldehyde and diethylphosphite, while the aminophosphonic acids were obtained by acid hydrolysis. All the molecules synthesized were characterized by the usual physico-chemical methods (TLC, IR, UV-Vis, etc.). Then, they were subjected to in vitro experiments, in order to determine their biological activities (antioxidant and anti-inflammatory activity). Finally, the computer tool was used for the theoretical study of the structural and electronic properties by the Density Functional Theory (DFT), using the Gaussian09 software, The obtained results are very satisfactory. Côte titre : MACH/0293 En ligne : https://drive.google.com/file/d/1H7_KQUTvZoewGSegiEsgi3ECclcyinta/view?usp=drive [...] Format de la ressource électronique : pdf Synthèse, caractérisation, évaluation biologique et étude théorique par DFT d’esters aminophosphonates et acides aminophosphoniques dérivés d’aminoalcool. [texte imprimé] / Aicha Yassa ; Rahma May ; Abdelkader Hellal, Directeur de thèse . - [S.l.] : Sétif:UFA1, 2023 . - 1 vol. (82 f.). ISSN : Synthèse, caractérisation, évaluation biologique e Langues : Français (fre) Catégories : Thèses & Mémoires:Chimie Mots-clés : α-aminophosphonate ester α-aminophosphonic acid Kabachnik-Fields reaction, DFT Antioxidant anti-inflammatory Résumé : This work was devoted for the synthesis of two series of α-aminophosphonates from two aliphatic amines with different carbon chains, to see the influence of chain length on the physicochemical properties, biological activities, as well as on the quantum properties of the obtained molecules. The aminophosphonate esters were synthesized, under microwave, via the Kabachnik-Fields reaction, from a primary amine, acetaldehyde and diethylphosphite, while the aminophosphonic acids were obtained by acid hydrolysis. All the molecules synthesized were characterized by the usual physico-chemical methods (TLC, IR, UV-Vis, etc.). Then, they were subjected to in vitro experiments, in order to determine their biological activities (antioxidant and anti-inflammatory activity). Finally, the computer tool was used for the theoretical study of the structural and electronic properties by the Density Functional Theory (DFT), using the Gaussian09 software, The obtained results are very satisfactory. Côte titre : MACH/0293 En ligne : https://drive.google.com/file/d/1H7_KQUTvZoewGSegiEsgi3ECclcyinta/view?usp=drive [...] Format de la ressource électronique : pdf

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
MACH/0293	MACH/0293	Mémoire	Bibliothéque des sciences	Français	Disponible Disponible

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