Synthèse, caractérisation et évaluation des activités biologiques d’une série de phosphonates alpha-aminés / Ines Haddadi  

Public ISBD Titre : Synthèse, caractérisation et évaluation des activités biologiques d’une série de phosphonates alpha-aminés Type de document : document électronique Auteurs : Ines Haddadi, Auteur ; Abdelkader Hellal, Directeur de thèse Année de publication : 2024 Importance : 1 vol (101 f.) Format : 29 cm Langues : Français (fre) Catégories : Thèses & Mémoires:Chimie Mots-clés : α-aminophosphonate, microwave, DFT, antioxidant, antibacterial, antifungal Index. décimale : 204- chimie Résumé : During this work, a synthesis of three α-aminophosphonate derivatives was developed: two α-aminophosphonate esters and an α-aminophosphonic acid. The derivatives were synthesized by two methods: a classic reflux method and another under microwave with the aim of choosing the right method in terms of yield and reaction time through a comparative study. α-Aminophosphonic acid (MTA) and α-aminophosphonate ester (MTE) were synthesized from m-toluidine, while α-aminophosphonate ester was synthesized from 2-amino-5-methylphenol. All the compounds obtained were characterized by spectroscopic microanalysis methods: UV-Vis, FT-IR, 1H- NMR and 31P-NMR. The analysis results are in good agreement with the proposed structures. The DFT theory calculations were carried out using the Gaussian09 software, using the 6-31G++(d,p) basis. The energies of the limiting orbitals were presented and used to predict global reactivity indices. Mulliken atomic charges, dipole moment and thermodynamic properties were also calculated and discussed. Additionally, the target compounds were evaluated for their antioxidant, antimicrobial, and enzymatic activities in vitro. Biological assays indicated that these compounds exhibited potent acetylcholinesterase and butyrylcholinesterase inhibitory activity. They have also proven to be excellent antioxidant agents, possessing remarkable antibacterial and antifungal properties Côte titre : Dch/0036 En ligne : http://dspace.univ-setif.dz:8888/jspui/handle/123456789/4374 Synthèse, caractérisation et évaluation des activités biologiques d’une série de phosphonates alpha-aminés [document électronique] / Ines Haddadi, Auteur ; Abdelkader Hellal, Directeur de thèse . - 2024 . - 1 vol (101 f.) ; 29 cm. Langues : Français (fre) Catégories : Thèses & Mémoires:Chimie Mots-clés : α-aminophosphonate, microwave, DFT, antioxidant, antibacterial, antifungal Index. décimale : 204- chimie Résumé : During this work, a synthesis of three α-aminophosphonate derivatives was developed: two α-aminophosphonate esters and an α-aminophosphonic acid. The derivatives were synthesized by two methods: a classic reflux method and another under microwave with the aim of choosing the right method in terms of yield and reaction time through a comparative study. α-Aminophosphonic acid (MTA) and α-aminophosphonate ester (MTE) were synthesized from m-toluidine, while α-aminophosphonate ester was synthesized from 2-amino-5-methylphenol. All the compounds obtained were characterized by spectroscopic microanalysis methods: UV-Vis, FT-IR, 1H- NMR and 31P-NMR. The analysis results are in good agreement with the proposed structures. The DFT theory calculations were carried out using the Gaussian09 software, using the 6-31G++(d,p) basis. The energies of the limiting orbitals were presented and used to predict global reactivity indices. Mulliken atomic charges, dipole moment and thermodynamic properties were also calculated and discussed. Additionally, the target compounds were evaluated for their antioxidant, antimicrobial, and enzymatic activities in vitro. Biological assays indicated that these compounds exhibited potent acetylcholinesterase and butyrylcholinesterase inhibitory activity. They have also proven to be excellent antioxidant agents, possessing remarkable antibacterial and antifungal properties Côte titre : Dch/0036 En ligne : http://dspace.univ-setif.dz:8888/jspui/handle/123456789/4374

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
DCH/0036	DCH/0036	Thèse	Bibliothéque des sciences	Français	Disponible Disponible

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