On the: Comparative clinical dosimetric study between the two IMRT techniques Sliding Window and Step & Shoot: Case of prostate cancer / Amani Makhloufi

Public ISBD Titre : On the: Comparative clinical dosimetric study between the two IMRT techniques Sliding Window and Step & Shoot: Case of prostate cancer Type de document : document électronique Auteurs : Amani Makhloufi, Auteur ; Saad Khoudri, Directeur de thèse Editeur : Setif:UFA Année de publication : 2024 Importance : 1 vol (65 f.) Format : 29 cm Langues : Anglais (eng) Catégories : Thèses & Mémoires:Physique Mots-clés : Physique Index. décimale : 530 - Physique Résumé : Prostate cancer is one of the most common diseases among men, requiring precise and effective therapeutic approaches. Among the treatment options, intensitymodulated radiotherapy stands out for its ability to target the tumor with great precision while minimizing side effects The aim of our study was to compare the two methods of intensity-modulated radiotherapy in terms of planned target volume coverage and protection of organs at risk, and to determine which the best method for treating prostate cancer is. Initially, the results of the analysis show that the dynamic method is better than the segmented method in terms of planned target volume coverage, thus providing better tumor destruction with the dynamic method. However, in terms of protecting organs at risk, the segmented method offers better protection, thus reducing late complications with the segmented method. In radiotherapy, protecting organs at risk takes priority over planned target volume coverage. However, in our study, dose constraints are respected for both techniques, so the determining factor for the best technique is the planned target volume coverage Note de contenu : Sommaire I. Cancer de prostate …………………………………………………………………………........3 I.1 Anatomie de la prostate……………………………………………………………………………………………4 I.2 Cancer de prostate…………………………………………………………………………………………………..5 I.2.1 Nature et facteurs de risques………………………………………………………………………………….5 I.2.2 Dépistage et diagnostic…………………………………………………………………………………………6 I.2.3 Classification de cancer de prostate………………………………………………………………………..7 I.3 Techniques de thérapie……………………………………………………………………….…..……………...8 I.4 Définition des volumes d’intérêt……………………………………..………………………………..……..8 I.4.1 Volume cible………………………………………………………………………………………………..……...9 I.4.1.1 GTV(Gross Tumor Volume)……………………………………………………………………..………...9 I.4.1.2 CTV(Clinical Target Volume).…………………………………………………………..………………...9 I.4.1.3 PTV(Planning Target Volume)..…………………………………………………………..……………...9 I.4.2 Organe à risque..……………………………………………………………………………………….………..10 I.4.2.1 Rectum………………………………………………………………………………………………….....……...10 I.4.2.2 Vessie……………………………………………………………………………………………………………….10 I.4.2.3 Tètes fémorales……………………………………………………………….…………………………………10 I.4.2.4 Urètre…………………………………………………………………………………..…………………………..11 I.5 Indication thérapeutique………………………………………………………………………………………….11 I.6 Technique d’irradiation avec modulation d’intensité…………………………………………………..11 II. Radiothérapie conformationnelle avec modulation d’intensité……..………….13 II.1 Présentation de la radiothérapie…………………………………………………………………………..….14 II.2 Evolution de la radiothérapie :Focus sur l’IMRT……………………………………………………....14 II.3 Radiothérapie Conformationnelle aves Modulation d’Intensité…………………….……………15 II.3.1Planification inverse…………………………………………………………………………………….…….…17 II.3.2 La fonction objectif……………………………………………………………………………………………..19 II.3.3 Méthode de réalisation des faisceaux modulés……………………………………………..………..19 II.3.3.1 Collimateur mutilâmes……………………………………………………………………………………...19 II.3.3.2 Les techniques d’IMRT……………………………………………………………………………………..21 II.3.3.2.1 La méthode segmentée (Statique)……………………………………………………………….…..22 II.3.3.2.2 La méthode dynamique……………………………………………………………………………...….23 III. Expérimentation : Méthode et patients……………………………………………..…..25 III.1 Objectif………………………………………………………………………………………………………………..26 III.2 Matériel……………………………………………………………………………………….……………………...26 III.3 Description des données…………………………………………………………………….………………...28 III.4 Prescription de dose………………………………………………………….…………………………………29 III.5 Définition de la balistique…………………………………………………………………………………..…29 III.6 L’optimisation………………………………………………………………………………………………..……30 III.6.1 Les volumes d’optimisation……………………………………………………………………………..….30 III.6.2 Les contraintes d’optimisation…………………………………………….………………………………32 III.7 Outils d’analyses…………………………………………………………………………………………………..34 III.7.1 Outils d’analyse qualitative…………………………………………………………………..……………..34 III.7.1.1 Courbe isodose……………………………………………………………………………………….………..35 III.7.1.2 HVD(Histogramme Volume Dose)………………………………………………..…………………..35 III.7.2 Outils d’analyse quantitative………………………………………………………………….…………...35 III.8 Objectif pour le PTV……………………………………………………………………………….…………….40 III.9 Objectif pour OAR………………………………………………………………………………………………..41 III.10 Résultats analyse………………………………………………………………………………………………..41 III.10.1 Résultats analyse qualitative……………………………………………………………………………..41 III.10.2 Résultats analyse quantitative………………………………………………………….……………….49 III.11 Analyses des résultats……………………………………………………………………..……………………53 III.11.1 Analyses qualitative…………………………………………………………………………….…………….53 III.11.1.1 Analyses des histogrammes doses volumes………………………………………..………………54 III.11.1.2 Analyses des courbes isodoses……………………………………………………………………..…..55 III.11.2 Analyses quantitatives……………………………………………………………………………………….55 III.12 Discussion………………………………………………………………………………………………..………..57 Côte titre : MAPH/0630 On the: Comparative clinical dosimetric study between the two IMRT techniques Sliding Window and Step & Shoot: Case of prostate cancer [document électronique] / Amani Makhloufi, Auteur ; Saad Khoudri, Directeur de thèse . - [S.l.] : Setif:UFA, 2024 . - 1 vol (65 f.) ; 29 cm. Langues : Anglais (eng) Catégories : Thèses & Mémoires:Physique Mots-clés : Physique Index. décimale : 530 - Physique Résumé : Prostate cancer is one of the most common diseases among men, requiring precise and effective therapeutic approaches. Among the treatment options, intensitymodulated radiotherapy stands out for its ability to target the tumor with great precision while minimizing side effects The aim of our study was to compare the two methods of intensity-modulated radiotherapy in terms of planned target volume coverage and protection of organs at risk, and to determine which the best method for treating prostate cancer is. Initially, the results of the analysis show that the dynamic method is better than the segmented method in terms of planned target volume coverage, thus providing better tumor destruction with the dynamic method. However, in terms of protecting organs at risk, the segmented method offers better protection, thus reducing late complications with the segmented method. In radiotherapy, protecting organs at risk takes priority over planned target volume coverage. However, in our study, dose constraints are respected for both techniques, so the determining factor for the best technique is the planned target volume coverage Note de contenu : Sommaire I. Cancer de prostate …………………………………………………………………………........3 I.1 Anatomie de la prostate……………………………………………………………………………………………4 I.2 Cancer de prostate…………………………………………………………………………………………………..5 I.2.1 Nature et facteurs de risques………………………………………………………………………………….5 I.2.2 Dépistage et diagnostic…………………………………………………………………………………………6 I.2.3 Classification de cancer de prostate………………………………………………………………………..7 I.3 Techniques de thérapie……………………………………………………………………….…..……………...8 I.4 Définition des volumes d’intérêt……………………………………..………………………………..……..8 I.4.1 Volume cible………………………………………………………………………………………………..……...9 I.4.1.1 GTV(Gross Tumor Volume)……………………………………………………………………..………...9 I.4.1.2 CTV(Clinical Target Volume).…………………………………………………………..………………...9 I.4.1.3 PTV(Planning Target Volume)..…………………………………………………………..……………...9 I.4.2 Organe à risque..……………………………………………………………………………………….………..10 I.4.2.1 Rectum………………………………………………………………………………………………….....……...10 I.4.2.2 Vessie……………………………………………………………………………………………………………….10 I.4.2.3 Tètes fémorales……………………………………………………………….…………………………………10 I.4.2.4 Urètre…………………………………………………………………………………..…………………………..11 I.5 Indication thérapeutique………………………………………………………………………………………….11 I.6 Technique d’irradiation avec modulation d’intensité…………………………………………………..11 II. Radiothérapie conformationnelle avec modulation d’intensité……..………….13 II.1 Présentation de la radiothérapie…………………………………………………………………………..….14 II.2 Evolution de la radiothérapie :Focus sur l’IMRT……………………………………………………....14 II.3 Radiothérapie Conformationnelle aves Modulation d’Intensité…………………….……………15 II.3.1Planification inverse…………………………………………………………………………………….…….…17 II.3.2 La fonction objectif……………………………………………………………………………………………..19 II.3.3 Méthode de réalisation des faisceaux modulés……………………………………………..………..19 II.3.3.1 Collimateur mutilâmes……………………………………………………………………………………...19 II.3.3.2 Les techniques d’IMRT……………………………………………………………………………………..21 II.3.3.2.1 La méthode segmentée (Statique)……………………………………………………………….…..22 II.3.3.2.2 La méthode dynamique……………………………………………………………………………...….23 III. Expérimentation : Méthode et patients……………………………………………..…..25 III.1 Objectif………………………………………………………………………………………………………………..26 III.2 Matériel……………………………………………………………………………………….……………………...26 III.3 Description des données…………………………………………………………………….………………...28 III.4 Prescription de dose………………………………………………………….…………………………………29 III.5 Définition de la balistique…………………………………………………………………………………..…29 III.6 L’optimisation………………………………………………………………………………………………..……30 III.6.1 Les volumes d’optimisation……………………………………………………………………………..….30 III.6.2 Les contraintes d’optimisation…………………………………………….………………………………32 III.7 Outils d’analyses…………………………………………………………………………………………………..34 III.7.1 Outils d’analyse qualitative…………………………………………………………………..……………..34 III.7.1.1 Courbe isodose……………………………………………………………………………………….………..35 III.7.1.2 HVD(Histogramme Volume Dose)………………………………………………..…………………..35 III.7.2 Outils d’analyse quantitative………………………………………………………………….…………...35 III.8 Objectif pour le PTV……………………………………………………………………………….…………….40 III.9 Objectif pour OAR………………………………………………………………………………………………..41 III.10 Résultats analyse………………………………………………………………………………………………..41 III.10.1 Résultats analyse qualitative……………………………………………………………………………..41 III.10.2 Résultats analyse quantitative………………………………………………………….……………….49 III.11 Analyses des résultats……………………………………………………………………..……………………53 III.11.1 Analyses qualitative…………………………………………………………………………….…………….53 III.11.1.1 Analyses des histogrammes doses volumes………………………………………..………………54 III.11.1.2 Analyses des courbes isodoses……………………………………………………………………..…..55 III.11.2 Analyses quantitatives……………………………………………………………………………………….55 III.12 Discussion………………………………………………………………………………………………..………..57 Côte titre : MAPH/0630

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
MAPH/0630	MAPH/0630	Mémoire	Bibliothéque des sciences	Anglais	Disponible Disponible

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