Radioiodine Therapy: Comparison of Optimizing Therapeutic Activity Calculation Models / Alaâ Errehmane Mihoubi

Public ISBD Titre : Radioiodine Therapy: Comparison of Optimizing Therapeutic Activity Calculation Models Type de document : document électronique Auteurs : Alaâ Errehmane Mihoubi, Auteur ; Zine El Abidine Chaoui, Directeur de thèse Editeur : Setif:UFA Année de publication : 2025 Importance : 1 vol (68 f.) Format : 29 cm Langues : Anglais (eng) Catégories : Thèses & Mémoires:Physique Mots-clés : Graves’ disease Radioiodine therapy Thyroid volume Dosimetric models Index. décimale : 530 - Physique Résumé : Introduction: Graves’ disease requires tailored radioiodine (¹³¹I) therapy due to variable thyroid volume and iodine uptake. Methods: Retrospective study on 4 patients at Annaba Cancer Center. Thyroid volume was measured by ultrasound; iodine uptake and effective half-life (Teff) via Atomlab 960. Compared four models: Marinelli formula, fixed-dose, non-dosimetric, and MIRD schema. Results: MIRD model was most precise (3.8–14.1 mCi), adjusting for gland size and uptake. Marinelli provided practical balance (3.4–9.3 mCi). Non-dosimetric models risked underdosing small glands. Fixed protocols lacked flexibility for prolonged Teff. Conclusions: MIRD offers best personalization but needs advanced tools. Marinelli is suitable where resources are limited. AI-based dosimetry may improve future precision. Note de contenu : Sommaire Côte titre : MAPH/0713 Radioiodine Therapy: Comparison of Optimizing Therapeutic Activity Calculation Models [document électronique] / Alaâ Errehmane Mihoubi, Auteur ; Zine El Abidine Chaoui, Directeur de thèse . - [S.l.] : Setif:UFA, 2025 . - 1 vol (68 f.) ; 29 cm. Langues : Anglais (eng) Catégories : Thèses & Mémoires:Physique Mots-clés : Graves’ disease Radioiodine therapy Thyroid volume Dosimetric models Index. décimale : 530 - Physique Résumé : Introduction: Graves’ disease requires tailored radioiodine (¹³¹I) therapy due to variable thyroid volume and iodine uptake. Methods: Retrospective study on 4 patients at Annaba Cancer Center. Thyroid volume was measured by ultrasound; iodine uptake and effective half-life (Teff) via Atomlab 960. Compared four models: Marinelli formula, fixed-dose, non-dosimetric, and MIRD schema. Results: MIRD model was most precise (3.8–14.1 mCi), adjusting for gland size and uptake. Marinelli provided practical balance (3.4–9.3 mCi). Non-dosimetric models risked underdosing small glands. Fixed protocols lacked flexibility for prolonged Teff. Conclusions: MIRD offers best personalization but needs advanced tools. Marinelli is suitable where resources are limited. AI-based dosimetry may improve future precision. Note de contenu : Sommaire Côte titre : MAPH/0713

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
MAPH/0713	MAPH/0713	Mémoire	Bibliothèque des sciences	Anglais	Disponible Disponible

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