Titre :	Burger's Medicinal chemistry, drug discovery and development Vol. 2 : Discovering lead molecules
Type de document :	texte imprimé
Auteurs :	Alfred Burger (1905-2000), Editeur scientifique ; Donald J. Abraham (1936-2021), Editeur scientifique ; David P. Rotella, Editeur scientifique
Editeur :	Wiley Blackwell
Année de publication :	2010
Importance :	1 vol. (927 p.)
Présentation :	ill., couv. ill. en coul.
Format :	27 cm
ISBN/ISSN/EAN :	978-0-471-37028-4
Langues :	Français
Catégories :	Pharmacologie
Mots-clés :	- Pharmaceutical chemistry - Drug development - Lead molecules - Chemistry Pharmaceutical - Molécules plomb - Chimie pharmaceutique - Développement de médicaments - Chimie pharmaceutique
Index. décimale :	615.1 Médicaments
Résumé :	This is Volume 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.
Note de contenu :	Sommaire: -1- Virtual screening -2- ADMET in vitro profiling : utility and applications in lead discovery -3- Retrometabolism-based drug design and targeting -4- New strategies for natural products lead generation -5- Microbes to man : from soils and the depths to drugs -6- Multiobjective optimization for drug discovery -7- GPCR homology model development and application -8- Structural alerts for toxicity -9- Protein-protein interactions as drug discovery targets -10- NMR-based screening and drug discovery -11- Drug transport and membrane transport proteins -12- Receptor targets in drug discovery -13- Selective toxicity -14- Chemogenomics : systematization of drug discovery -15- Docking and scoring in drug discovery -16- Recent trends in structure-based drug design and energetics -17- QM and QM-MM approaches to evaluating binding affinities -18- Assessing the bioavailability of drug delivery systems : mathematical modeling -19- Protein flexibility in in silico screening

Burger's Medicinal chemistry, drug discovery and development Vol. 2 : Discovering lead molecules [texte imprimé] / Alfred Burger (1905-2000), Editeur scientifique ; Donald J. Abraham (1936-2021), Editeur scientifique ; David P. Rotella, Editeur scientifique . - [S.l.] : Wiley Blackwell, 2010 . - 1 vol. (927 p.) : ill., couv. ill. en coul. ; 27 cm.
ISBN : 978-0-471-37028-4
Langues : Français

Catégories :	Pharmacologie
Mots-clés :	- Pharmaceutical chemistry - Drug development - Lead molecules - Chemistry Pharmaceutical - Molécules plomb - Chimie pharmaceutique - Développement de médicaments - Chimie pharmaceutique
Index. décimale :	615.1 Médicaments
Résumé :	This is Volume 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.
Note de contenu :	Sommaire: -1- Virtual screening -2- ADMET in vitro profiling : utility and applications in lead discovery -3- Retrometabolism-based drug design and targeting -4- New strategies for natural products lead generation -5- Microbes to man : from soils and the depths to drugs -6- Multiobjective optimization for drug discovery -7- GPCR homology model development and application -8- Structural alerts for toxicity -9- Protein-protein interactions as drug discovery targets -10- NMR-based screening and drug discovery -11- Drug transport and membrane transport proteins -12- Receptor targets in drug discovery -13- Selective toxicity -14- Chemogenomics : systematization of drug discovery -15- Docking and scoring in drug discovery -16- Recent trends in structure-based drug design and energetics -17- QM and QM-MM approaches to evaluating binding affinities -18- Assessing the bioavailability of drug delivery systems : mathematical modeling -19- Protein flexibility in in silico screening