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Affiner la rechercheAnti-inflammatory and antioxidant effect of flavonoids Catechin , Rutin , Fisetin and Morin / Chaima Souiki / Sétif : Faculté des Sciences de la Nature et de la Vie (2024)
Titre : Anti-inflammatory and antioxidant effect of flavonoids Catechin , Rutin , Fisetin and Morin Type de document : document électronique Auteurs : Chaima Souiki, Auteur ; Hichem Meziti, Directeur de thèse Editeur : Sétif : Faculté des Sciences de la Nature et de la Vie Année de publication : 2024 Importance : 60 Feuilles ISBN/ISSN/EAN : MS/2135 Langues : Anglais Catégories : Thèse et mémoire:Master:Biotechnologie et pathologie moléculaire Mots-clés : Anti-inflammatory Antioxidant Catechin fisetin Rutin Morin MPO Elastase. Résumé :
The purpose of this research was to assess how pure flavonoids (Catechin, Fisetin, Rutin, and Morin) affect inflammation and oxidative stress, particularly in terms of their impact on AAPH-induced hemolysis, Myeloperoxidase, and Elastase activities. The study evaluated the antioxidant properties of these flavonoids in vitro and found they provided substantial protection against AAPH-induced red blood cell hemolysis. There was a clear relationship observed between the concentration of flavonoids and the time taken to achieve half-hemolysis (HT50), indicating their potential as antioxidants. The observed half-hemolysis time (HT50) values in the anti-hemolytic assay were as follows: for catechin at 5 and 1 μg/ml, the HT50 values were 4.22 h and 3.83 h, respectively, indicating significant effects. Fisetin showed HT50 values of 3.58 h and 1.98 h at 5 and 1 μg/ml, respectively. Rutin exhibited HT50 values of 2.95 h and non -significant effect of 1.65 h at 5 and 1 μg/ml, respectively. Morin demonstrated non-significant effects with HT50 values of 1.92 h and 2.04 h. The research on flavonoids also revealed notable inhibition of elastase and MPO activities. The anti-inflammatory properties were validated by assessing how flavonoids inhibit both elastase and neutrophil myeloperoxidase activities. The flavonoids gave the following inhibitory effects on myeloperoxidase activity: morin and catechin demonstrated high inhibition rates of 67.26% and 70.33% at 5 μg/ml, and 38.47% and 39.92% at 1 μg/ml.followed by Fisetin and Rutin with lower effect (40,34% and 29,23% at 5μg/ml, and 41,38% and ,22.14% at 1μg/ml).The effect on elastase activity was as following: Catechin had significant effect at both concentrations 10μg/ml and 5μg/ml with inhibition percentage of 18,08% and 11,42% respectively. Fisetin also had significant effect at both concentrations with 19,02% at 10 μg/ml and 13,72 % at 5μg/ml. Morin had non-significant effect whith both concentrations (0,69% and 1,10 %). Rutin showed a moderated effect at concentration 1 μg/ml with 5,27% inhibition, and non-significant inhibition 3.32% at concentration 5μg/ml.The results obtained indicate that flavonoids exhibit significant effects in reducing hemolysis, acting as antioxidants, and displaying anti-inflammatory properties.Anti-inflammatory and antioxidant effect of flavonoids Catechin , Rutin , Fisetin and Morin [document électronique] / Chaima Souiki, Auteur ; Hichem Meziti, Directeur de thèse . - Sétif : Faculté des Sciences de la Nature et de la Vie, 2024 . - 60 Feuilles.
ISSN : MS/2135
Langues : Anglais
Catégories : Thèse et mémoire:Master:Biotechnologie et pathologie moléculaire Mots-clés : Anti-inflammatory Antioxidant Catechin fisetin Rutin Morin MPO Elastase. Résumé :
The purpose of this research was to assess how pure flavonoids (Catechin, Fisetin, Rutin, and Morin) affect inflammation and oxidative stress, particularly in terms of their impact on AAPH-induced hemolysis, Myeloperoxidase, and Elastase activities. The study evaluated the antioxidant properties of these flavonoids in vitro and found they provided substantial protection against AAPH-induced red blood cell hemolysis. There was a clear relationship observed between the concentration of flavonoids and the time taken to achieve half-hemolysis (HT50), indicating their potential as antioxidants. The observed half-hemolysis time (HT50) values in the anti-hemolytic assay were as follows: for catechin at 5 and 1 μg/ml, the HT50 values were 4.22 h and 3.83 h, respectively, indicating significant effects. Fisetin showed HT50 values of 3.58 h and 1.98 h at 5 and 1 μg/ml, respectively. Rutin exhibited HT50 values of 2.95 h and non -significant effect of 1.65 h at 5 and 1 μg/ml, respectively. Morin demonstrated non-significant effects with HT50 values of 1.92 h and 2.04 h. The research on flavonoids also revealed notable inhibition of elastase and MPO activities. The anti-inflammatory properties were validated by assessing how flavonoids inhibit both elastase and neutrophil myeloperoxidase activities. The flavonoids gave the following inhibitory effects on myeloperoxidase activity: morin and catechin demonstrated high inhibition rates of 67.26% and 70.33% at 5 μg/ml, and 38.47% and 39.92% at 1 μg/ml.followed by Fisetin and Rutin with lower effect (40,34% and 29,23% at 5μg/ml, and 41,38% and ,22.14% at 1μg/ml).The effect on elastase activity was as following: Catechin had significant effect at both concentrations 10μg/ml and 5μg/ml with inhibition percentage of 18,08% and 11,42% respectively. Fisetin also had significant effect at both concentrations with 19,02% at 10 μg/ml and 13,72 % at 5μg/ml. Morin had non-significant effect whith both concentrations (0,69% and 1,10 %). Rutin showed a moderated effect at concentration 1 μg/ml with 5,27% inhibition, and non-significant inhibition 3.32% at concentration 5μg/ml.The results obtained indicate that flavonoids exhibit significant effects in reducing hemolysis, acting as antioxidants, and displaying anti-inflammatory properties.Exemplaires
Code-barres Cote Support Localisation Section Disponibilité MS/2135 BPM/CD 27 DVD et CD Bibliothèque SNV Englais Disponible 
Titre : Anti-oxidant and anti-inflammatory effects of plant métabolites Type de document : document électronique Auteurs : SCovia Nuwenyine, Auteur ; Tracey. A Chida, Auteur ; Hichem Meziti, Directeur de thèse Editeur : Sétif [Algérie] : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1 Année de publication : 2024 Importance : 83 Feuilles Format : ISBN/ISSN/EAN : MS/1984 Langues : Français Catégories : Thèse et mémoire:Master:Biochimie appliquée Mots-clés : -Anti-inflammatory Antioxidan plant métabolites. Résumé :
The aim of this study was to determine the anti-inflammatory and antioxidant activity of flavonoids (genistein, gossypin, myricetin, silymarin, diosmin, naringin, Quercetin,), phenolic acids (caffeic acid, gallic acid) and other plant metabolites (astaxanthin and vitamin C) on AAPH- induced hemolysis, myeloperoxidase and elastase activities. The in vitro antioxidant activity of flavonoids and other plant metabolites was evaluated and exerted a significant protective effect against AAPH-induced erythrocyte hemolysis, with a good correlation between concentration and half-hemolysis time (HT50). The plant metabolite that exhibited the highest anti-hemolytic effect was caffeic acid with half- hemolysis times of 3.44 and 2.62 hours at 5and 1 μg /ml respectively silymarin and astaxanthin had the lowest effect in comparison with the other plant metabolite. The study of plant metabolites showed also significant inhibitory effects on elastase and MPO activities. The anti-inflammatory activity was confirmed by evaluating the effects of plant metabolites on inhibition of elastase activity and neutrophil myeloperoxidase activity. The plant metabolites with the highest inhibition effect on MPO activity was caffeic acid with inhibition percentage of 93.65% and 59.6% at 5 and 1 μg /ml) while astaxanthin had the lowest effect with 4.72% and -14.15% at concentrations 5 and 1 μ. The plant metabolites also inhibited neutrophil elastase activity with vitamin C exhibiting the highest inhibition effect of 24.75% and 23% at 10 and 5 μ while silymarin had the lowest inhibition effect of 0% at 10 /ml and 6.25% at 5 /ml. The obtained results showed that plant metabolites have considerable antihemolytic, antioxidant, and anti-inflammatory effects.En ligne : http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/5614/1/BAPP-CD210---- [...] Anti-oxidant and anti-inflammatory effects of plant métabolites [document électronique] / SCovia Nuwenyine, Auteur ; Tracey. A Chida, Auteur ; Hichem Meziti, Directeur de thèse . - Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2024 . - 83 Feuilles ; PDF.
ISSN : MS/1984
Langues : Français
Catégories : Thèse et mémoire:Master:Biochimie appliquée Mots-clés : -Anti-inflammatory Antioxidan plant métabolites. Résumé :
The aim of this study was to determine the anti-inflammatory and antioxidant activity of flavonoids (genistein, gossypin, myricetin, silymarin, diosmin, naringin, Quercetin,), phenolic acids (caffeic acid, gallic acid) and other plant metabolites (astaxanthin and vitamin C) on AAPH- induced hemolysis, myeloperoxidase and elastase activities. The in vitro antioxidant activity of flavonoids and other plant metabolites was evaluated and exerted a significant protective effect against AAPH-induced erythrocyte hemolysis, with a good correlation between concentration and half-hemolysis time (HT50). The plant metabolite that exhibited the highest anti-hemolytic effect was caffeic acid with half- hemolysis times of 3.44 and 2.62 hours at 5and 1 μg /ml respectively silymarin and astaxanthin had the lowest effect in comparison with the other plant metabolite. The study of plant metabolites showed also significant inhibitory effects on elastase and MPO activities. The anti-inflammatory activity was confirmed by evaluating the effects of plant metabolites on inhibition of elastase activity and neutrophil myeloperoxidase activity. The plant metabolites with the highest inhibition effect on MPO activity was caffeic acid with inhibition percentage of 93.65% and 59.6% at 5 and 1 μg /ml) while astaxanthin had the lowest effect with 4.72% and -14.15% at concentrations 5 and 1 μ. The plant metabolites also inhibited neutrophil elastase activity with vitamin C exhibiting the highest inhibition effect of 24.75% and 23% at 10 and 5 μ while silymarin had the lowest inhibition effect of 0% at 10 /ml and 6.25% at 5 /ml. The obtained results showed that plant metabolites have considerable antihemolytic, antioxidant, and anti-inflammatory effects.En ligne : http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/5614/1/BAPP-CD210---- [...] Exemplaires
Code-barres Cote Support Localisation Section Disponibilité MS/1984 BAPP/CD210 DVD et CD Bibliothèque SNV Englais Disponible
Titre : L'auto-immunité et les nouvelles approches thérapeutiques. Type de document : document électronique Auteurs : Imane Saad azzem, Auteur ; Imane Moufek, Auteur ; Hichem Meziti, Directeur de thèse Editeur : Faculté des sciences de la nature et de la vie Année de publication : 2022 Importance : 54 Feuilles ISBN/ISSN/EAN : CD/1020 Langues : Français Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : L’auto-immunité Les maladies auto-immunes Nouvelles biothérapie. Résumé :
L'Auto-immunité est la rupture des mécanismes de tolérance conduisant à l’action Pathogène du système immunitaire contre les constituants naturels de l’organisme et à l’apparition de maladies dites auto-immunes. les maladies auto-immunes sont la troisième cause de mortalité dans les pays développés, est sont classées en deux groupes : les maladies spécifiques d’organe et non spécifiques d’organe (systémiques), il y a trois facteurs sont en jeu dans la pathogenèse des MAI : les gènes, les facteurs endogènes et l’environnement, plusieurs éléments sont utilisés pour le diagnostiquer, notamment biologiques qui permettent de suggéré certains traitements comme l'immunosuppression et l'immunomodulation ; ces traitements ont des effets secondaires. Au cours de la dernière décennie et j’usqu’a présente, les scientifiques sont a la recherche de nouvelles biothérapies plus efficaces et ayant moins d’effets indésirables pour le traitement des troubles de l'IA ; il s’agit notamment de : la technologie CRISPR/Cas9, l'AHSCT, la nouvelle génération d'AcM anti-CD20, blocage des molécules co-stimulatrices CTLA4, Modulation des cytokines, utilisation de LT régulateurs, modulation de microbiome, mécanismes immunomodilateurs de Trichinella spiralis.
En ligne : https://drive.google.com/file/d/14Hl7rZ02HqQosvX2MNDzx_7sWeOb_QmM/view?usp=shari [...] L'auto-immunité et les nouvelles approches thérapeutiques. [document électronique] / Imane Saad azzem, Auteur ; Imane Moufek, Auteur ; Hichem Meziti, Directeur de thèse . - Setif, Algerie : Faculté des sciences de la nature et de la vie, 2022 . - 54 Feuilles.
ISSN : CD/1020
Langues : Français
Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : L’auto-immunité Les maladies auto-immunes Nouvelles biothérapie. Résumé :
L'Auto-immunité est la rupture des mécanismes de tolérance conduisant à l’action Pathogène du système immunitaire contre les constituants naturels de l’organisme et à l’apparition de maladies dites auto-immunes. les maladies auto-immunes sont la troisième cause de mortalité dans les pays développés, est sont classées en deux groupes : les maladies spécifiques d’organe et non spécifiques d’organe (systémiques), il y a trois facteurs sont en jeu dans la pathogenèse des MAI : les gènes, les facteurs endogènes et l’environnement, plusieurs éléments sont utilisés pour le diagnostiquer, notamment biologiques qui permettent de suggéré certains traitements comme l'immunosuppression et l'immunomodulation ; ces traitements ont des effets secondaires. Au cours de la dernière décennie et j’usqu’a présente, les scientifiques sont a la recherche de nouvelles biothérapies plus efficaces et ayant moins d’effets indésirables pour le traitement des troubles de l'IA ; il s’agit notamment de : la technologie CRISPR/Cas9, l'AHSCT, la nouvelle génération d'AcM anti-CD20, blocage des molécules co-stimulatrices CTLA4, Modulation des cytokines, utilisation de LT régulateurs, modulation de microbiome, mécanismes immunomodilateurs de Trichinella spiralis.
En ligne : https://drive.google.com/file/d/14Hl7rZ02HqQosvX2MNDzx_7sWeOb_QmM/view?usp=shari [...] Exemplaires
Code-barres Cote Support Localisation Section Disponibilité CD/1020 IMM/CD117 DVD et CD Bibliothèque SNV Français Disponible
Titre : A Comprehensive Review of Celiac Disease : pathogenesis, Current Treatment Strategies, and the Therapeutic Potential of Medicinal Plants Type de document : document électronique Auteurs : Hadjer Bouchegroun, Auteur ; Manar Bouchegroun, Auteur ; Hichem Meziti, Directeur de thèse Editeur : Sétif [Algérie] : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1 Année de publication : 2025 Importance : 36 Feuilles Format : ISBN/ISSN/EAN : MS/2292 Langues : Anglais Catégories : Thèse et mémoire:Master:Biochimie appliquée Mots-clés : Celiac drsease (CD) Zonulin Tight junction (TJ) Résumé :
Celiac disease (CD) is a chronic, immune-mediated enteropathy triggered by gluten ingestion in genetically predisposed individuals, primarily involving the HLA-DQ2 and HLA-DQ8 haplotypes. The disease is characterized by intestinal inflammation, villous atrophy, and a wide spectrum of gastrointestinal and extraintestinal manifestations. While a strict lifelong gluten-free diet remains the cornerstone of therapy, it poses significant challenges related to dietary adherence, hidden gluten, and impact on quality of life.This thesis provides a comprehensive review of the pathogenesis of celiac disease, with a particular focus on the molecular and immunological mechanisms, including the role of gliadin peptides, zonulin-mediated intestinal permeability, and both innate and adaptive immune responses. Moreover, it outlines recent advances in therapeutic approaches beyond dietary restriction. These include enzyme-based gluten detoxification, transglutaminase 2 (TG2) inhibitors, immunomodulators, tight junction regulators, and probiotic and microbial therapies.In parallel, this work highlights the growing interest in medicinal plants as adjunct or alternative therapies. Notably, plant-derived compounds from green tea, cocoa, and turmeric demonstrate anti-inflammatory and immunomodulatory properties, with potential roles in preserving intestinal barrier integrity, reducing cytokine production, and modulating gut microbiota. Among them, curcumin stands out as a promising candidate due to its multifaceted biological activities targeting key mechanisms implicated in celiac disease pathogenesis.While these natural interventions show promise in preclinical studies, further clinical validation is necessary. This review underscores the importance of integrative approaches that combine conventional and evidence-based natural therapies to improve outcomes and quality of life for individuals with celiac disease.A Comprehensive Review of Celiac Disease : pathogenesis, Current Treatment Strategies, and the Therapeutic Potential of Medicinal Plants [document électronique] / Hadjer Bouchegroun, Auteur ; Manar Bouchegroun, Auteur ; Hichem Meziti, Directeur de thèse . - Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2025 . - 36 Feuilles ; PDF.
ISSN : MS/2292
Langues : Anglais
Catégories : Thèse et mémoire:Master:Biochimie appliquée Mots-clés : Celiac drsease (CD) Zonulin Tight junction (TJ) Résumé :
Celiac disease (CD) is a chronic, immune-mediated enteropathy triggered by gluten ingestion in genetically predisposed individuals, primarily involving the HLA-DQ2 and HLA-DQ8 haplotypes. The disease is characterized by intestinal inflammation, villous atrophy, and a wide spectrum of gastrointestinal and extraintestinal manifestations. While a strict lifelong gluten-free diet remains the cornerstone of therapy, it poses significant challenges related to dietary adherence, hidden gluten, and impact on quality of life.This thesis provides a comprehensive review of the pathogenesis of celiac disease, with a particular focus on the molecular and immunological mechanisms, including the role of gliadin peptides, zonulin-mediated intestinal permeability, and both innate and adaptive immune responses. Moreover, it outlines recent advances in therapeutic approaches beyond dietary restriction. These include enzyme-based gluten detoxification, transglutaminase 2 (TG2) inhibitors, immunomodulators, tight junction regulators, and probiotic and microbial therapies.In parallel, this work highlights the growing interest in medicinal plants as adjunct or alternative therapies. Notably, plant-derived compounds from green tea, cocoa, and turmeric demonstrate anti-inflammatory and immunomodulatory properties, with potential roles in preserving intestinal barrier integrity, reducing cytokine production, and modulating gut microbiota. Among them, curcumin stands out as a promising candidate due to its multifaceted biological activities targeting key mechanisms implicated in celiac disease pathogenesis.While these natural interventions show promise in preclinical studies, further clinical validation is necessary. This review underscores the importance of integrative approaches that combine conventional and evidence-based natural therapies to improve outcomes and quality of life for individuals with celiac disease.Exemplaires
Code-barres Cote Support Localisation Section Disponibilité MS/2292 BAPP/CD278 DVD et CD Bibliothèque SNV Englais Disponible
Titre : Effects of naringin on neutrophil activity in inflammation Type de document : document électronique Auteurs : Melody Magodo, Auteur ; Hichem Meziti, Directeur de thèse Editeur : Faculté des sciences de la nature et de la vie Année de publication : 2022 Importance : 54 Feuilles ISBN/ISSN/EAN : CD/1017 Langues : Français Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : Anti-inflammatory Degranulation Elastase Inflammation MPO,naringin Neutrophils. Résumé :
Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells including neutrophils, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. Flavonoids are naturally occurring plant compounds that have been demonstrated to possess a variety of anti-inflammatory effects. This study investigates the biological effects of naringin on five aspects of neutrophil function that are commonly considered to be associated with inflammation: myeloperoxidase release, elastase release, degranulation, chemotaxis and bactericidal activity. The results showed that naringin showed no significant inhibition of elastase activity and myeloperoxidase activity. In the degranulation by human neutrophils test, naringin showed a nonsignificant inhibition. In contrast, the bactericidal activity of neutrophils showed a significant inhibition 84% by naringin only at concentrations of 25 μg/ml and that of the control. Naringin at a concentration 1mg/mL also showed a significant inhibition of neutrophil migration in the chemotaxis of human neutrophils test. The present studies demonstrated that naringin like many flavonoids possess anti-inflammatory, antioxidant effects and has a protective effect on pathophysiology, reflecting its medicinal value. Furthermore, naringin has shown potential to become an alternative as a traditional anti-inflammatory drug, because it exerts less side effects than chemically synthesized drugsEn ligne : https://drive.google.com/file/d/1R4jYXOuas4oFbVTZggvHA_IJeOKZLEbn/view?usp=shari [...] Effects of naringin on neutrophil activity in inflammation [document électronique] / Melody Magodo, Auteur ; Hichem Meziti, Directeur de thèse . - Setif, Algerie : Faculté des sciences de la nature et de la vie, 2022 . - 54 Feuilles.
ISSN : CD/1017
Langues : Français
Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : Anti-inflammatory Degranulation Elastase Inflammation MPO,naringin Neutrophils. Résumé :
Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells including neutrophils, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. Flavonoids are naturally occurring plant compounds that have been demonstrated to possess a variety of anti-inflammatory effects. This study investigates the biological effects of naringin on five aspects of neutrophil function that are commonly considered to be associated with inflammation: myeloperoxidase release, elastase release, degranulation, chemotaxis and bactericidal activity. The results showed that naringin showed no significant inhibition of elastase activity and myeloperoxidase activity. In the degranulation by human neutrophils test, naringin showed a nonsignificant inhibition. In contrast, the bactericidal activity of neutrophils showed a significant inhibition 84% by naringin only at concentrations of 25 μg/ml and that of the control. Naringin at a concentration 1mg/mL also showed a significant inhibition of neutrophil migration in the chemotaxis of human neutrophils test. The present studies demonstrated that naringin like many flavonoids possess anti-inflammatory, antioxidant effects and has a protective effect on pathophysiology, reflecting its medicinal value. Furthermore, naringin has shown potential to become an alternative as a traditional anti-inflammatory drug, because it exerts less side effects than chemically synthesized drugsEn ligne : https://drive.google.com/file/d/1R4jYXOuas4oFbVTZggvHA_IJeOKZLEbn/view?usp=shari [...] Exemplaires
Code-barres Cote Support Localisation Section Disponibilité CD/1017 IMM/CD114 DVD et CD Bibliothèque SNV Français Disponible
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