Effects of naringin on neutrophil activity in inflammation / Melody Magodo / Faculté des sciences de la nature et de la vie (2022) 

Public ISBD Titre : Effects of naringin on neutrophil activity in inflammation Type de document : document électronique Auteurs : Melody Magodo, Auteur ; Hichem Meziti, Directeur de thèse Editeur : Faculté des sciences de la nature et de la vie Année de publication : 2022 Importance : 54 Feuilles ISBN/ISSN/EAN : CD/1017 Langues : Français Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : Anti-inflammatory  Degranulation  Elastase  Inflammation  MPO,naringin  Neutrophils. Résumé : Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells including neutrophils, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. Flavonoids are naturally occurring plant compounds that have been demonstrated to possess a variety of anti-inflammatory effects. This study investigates the biological effects of naringin on five aspects of neutrophil function that are commonly considered to be associated with inflammation: myeloperoxidase release, elastase release, degranulation, chemotaxis and bactericidal activity. The results showed that naringin showed no significant inhibition of elastase activity and myeloperoxidase activity. In the degranulation by human neutrophils test, naringin showed a nonsignificant inhibition. In contrast, the bactericidal activity of neutrophils showed a significant inhibition 84% by naringin only at concentrations of 25 μg/ml and that of the control. Naringin at a concentration 1mg/mL also showed a significant inhibition of neutrophil migration in the chemotaxis of human neutrophils test. The present studies demonstrated that naringin like many flavonoids possess anti-inflammatory, antioxidant effects and has a protective effect on pathophysiology, reflecting its medicinal value. Furthermore, naringin has shown potential to become an alternative as a traditional anti-inflammatory drug, because it exerts less side effects than chemically synthesized drugs En ligne : https://drive.google.com/file/d/1R4jYXOuas4oFbVTZggvHA_IJeOKZLEbn/view?usp=shari [...] Effects of naringin on neutrophil activity in inflammation [document électronique] / Melody Magodo, Auteur ; Hichem Meziti, Directeur de thèse . - Setif, Algerie : Faculté des sciences de la nature et de la vie, 2022 . - 54 Feuilles. ISSN : CD/1017 Langues : Français Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : Anti-inflammatory  Degranulation  Elastase  Inflammation  MPO,naringin  Neutrophils. Résumé : Inflammation is a central component of the immune response. In its acute form it aids the transition from disease to health via the activation of numerous immune cells including neutrophils, enabling them to reach the site of infection/injury and orchestrate themselves to combat pathogens, facilitating resolution and repair to restore the host to health. Flavonoids are naturally occurring plant compounds that have been demonstrated to possess a variety of anti-inflammatory effects. This study investigates the biological effects of naringin on five aspects of neutrophil function that are commonly considered to be associated with inflammation: myeloperoxidase release, elastase release, degranulation, chemotaxis and bactericidal activity. The results showed that naringin showed no significant inhibition of elastase activity and myeloperoxidase activity. In the degranulation by human neutrophils test, naringin showed a nonsignificant inhibition. In contrast, the bactericidal activity of neutrophils showed a significant inhibition 84% by naringin only at concentrations of 25 μg/ml and that of the control. Naringin at a concentration 1mg/mL also showed a significant inhibition of neutrophil migration in the chemotaxis of human neutrophils test. The present studies demonstrated that naringin like many flavonoids possess anti-inflammatory, antioxidant effects and has a protective effect on pathophysiology, reflecting its medicinal value. Furthermore, naringin has shown potential to become an alternative as a traditional anti-inflammatory drug, because it exerts less side effects than chemically synthesized drugs En ligne : https://drive.google.com/file/d/1R4jYXOuas4oFbVTZggvHA_IJeOKZLEbn/view?usp=shari [...]

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
CD/1017	IMM/CD114	DVD et CD	Bibliothèque SNV	Français	Disponible

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