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| Titre : | Anti-inflammatory, analgesic, anti-ulcer and anti-fungal activities of two Algerian endemic species | | Type de document : | document électronique | | Auteurs : | Nassima Mekhlouf, Auteur ; Ahkam Mezaghcha, Auteur ; Walid Mamache, Directeur de thèse | | Editeur : | Faculté des sciences de la nature et de la vie | | Année de publication : | 2023 | | ISBN/ISSN/EAN : | MS/1669 | | Langues : | Français | | Catégories : | Thèse et mémoire:Master:Biochimie appliquée
| | Mots-clés : | S.perralderianus S.giganteus Anti-inflammatory Analgesic effect AAPH. | | Résumé : |
The plants Senecio perralderianus and Senecio giganteus belong to the family Asteraceae and
are found exclusively in Algeria. The aerial parts of S. perralderianus and S. giganteus were
extracted using ethanol and water to obtain the following extracts: Sp Aq, Sp Eth, Sg Aq, and Sg
Eth. The Sp Eth demonstrated a strong analgesic effect by inhibiting acetic acid-induced
abdominal contractions by 81.61%. In contrast, the extract of Sg did not show any analgesic
effect. When applied topically at a dose of 2 mg/ear, the extracts of both S. perralderianus and S.
giganteus displayed anti-inflammatory activity against croton oil-induced ear edema. Sg Aq and
Sg Eth extracts exhibited inhibitions with values of 73.61 ± 8.78% and 68.05 ± 9.73%,
respectively. Mice were orally fed with 200 mg/kg of the plant extracts being studied and then
given HCl-ethanol. The extracts demonstrated a similar protective effect to omeprazole®, with a
range of protection between 68.38% and 75.78%. Furthermore, pre-treatment with the extracts
significantly increased protein content and levels of GSH, with slight increases in SOD and CAT
levels. The extracts also reduced lipid peroxidation. The antioxidant activity of the plant extracts
was confirmed invitro by their anti-hemolytic effect on erythrocytes against AAPH. Sp Aq
demonstrated a similar effect to Trolox, with an HT50 value of 179.2 ± 5.46 min. The studied
extracts also demonstrated a strong inhibition against the tested fungi. These activities could be
attributed to the presence of flavonoids, phenols, and caffeic acid compounds in the extracts of
the plants being studied. |
Anti-inflammatory, analgesic, anti-ulcer and anti-fungal activities of two Algerian endemic species [document électronique] / Nassima Mekhlouf, Auteur ; Ahkam Mezaghcha, Auteur ; Walid Mamache, Directeur de thèse . - Setif, Algerie : Faculté des sciences de la nature et de la vie, 2023. ISSN : MS/1669 Langues : Français | Catégories : | Thèse et mémoire:Master:Biochimie appliquée
| | Mots-clés : | S.perralderianus S.giganteus Anti-inflammatory Analgesic effect AAPH. | | Résumé : |
The plants Senecio perralderianus and Senecio giganteus belong to the family Asteraceae and
are found exclusively in Algeria. The aerial parts of S. perralderianus and S. giganteus were
extracted using ethanol and water to obtain the following extracts: Sp Aq, Sp Eth, Sg Aq, and Sg
Eth. The Sp Eth demonstrated a strong analgesic effect by inhibiting acetic acid-induced
abdominal contractions by 81.61%. In contrast, the extract of Sg did not show any analgesic
effect. When applied topically at a dose of 2 mg/ear, the extracts of both S. perralderianus and S.
giganteus displayed anti-inflammatory activity against croton oil-induced ear edema. Sg Aq and
Sg Eth extracts exhibited inhibitions with values of 73.61 ± 8.78% and 68.05 ± 9.73%,
respectively. Mice were orally fed with 200 mg/kg of the plant extracts being studied and then
given HCl-ethanol. The extracts demonstrated a similar protective effect to omeprazole®, with a
range of protection between 68.38% and 75.78%. Furthermore, pre-treatment with the extracts
significantly increased protein content and levels of GSH, with slight increases in SOD and CAT
levels. The extracts also reduced lipid peroxidation. The antioxidant activity of the plant extracts
was confirmed invitro by their anti-hemolytic effect on erythrocytes against AAPH. Sp Aq
demonstrated a similar effect to Trolox, with an HT50 value of 179.2 ± 5.46 min. The studied
extracts also demonstrated a strong inhibition against the tested fungi. These activities could be
attributed to the presence of flavonoids, phenols, and caffeic acid compounds in the extracts of
the plants being studied. |
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Affiner la rechercheAnti-inflammatory, analgesic, anti-ulcer and anti-fungal activities of two Algerian endemic species / Nassima Mekhlouf / Faculté des sciences de la nature et de la vie (2023)
