Evaluation of anti-inflammatory and anti-oxydant activity of the seeds of Silybum marianum L. / Niamat Allah Mili / Faculté des sciences de la nature et de la vie (2023)

Public ISBD Titre : Evaluation of anti-inflammatory and anti-oxydant activity of the seeds of Silybum marianum L. Type de document : document électronique Auteurs : Niamat Allah Mili, Auteur ; Nour Elhouda Semcha, Auteur ; Karbab,Ahlem, Directeur de thèse Editeur : Faculté des sciences de la nature et de la vie Année de publication : 2023 Importance : 41 Feuilles ISBN/ISSN/EAN : MS/1490 Langues : Français Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : Silyum marianum  Antioxidants  Anti-inflammatory  toxicity  Anticoagulant. Résumé : The Silybum marianum is one of the most important plants used in traditional medicine. It is an herbaceous plant from the asteraceae family and originally grows in the Mediterranean region.Our study aims to evaluate the antioxidant and anti-inflammatory activities, as well as the toxicity and anticoagulant properties of Silybum marianum seeds. We employed two extraction methods (soaking and boiling) and conducted qualitative and quantitative chemical analyses of these extracts. Additionally, we assessed the antioxidant activity using the DPPH free radical scavenging assay and the anti-inflammatory activity (in vivo) using the ear edema model. Furthermore, we evaluated the toxicity and anticoagulant activity. The results showed that the ethanolic extract had a higher yield percentage of 3.71% compared to the aqueous extract. The chemical analysis of Silybum marianum seeds revealed significant amounts of polyphenols, flavonoids, free quinones, and tannins, while saponins were absent. Regarding the anti-inflammatory and antioxidant activities, the ethanolic extract exhibited values of 84.56% and an inhibitory concentration of 0.24 mg/mL, respectively. The extracts did not cause any changes in behavior or mortality of the treated animals. The calculated lethal dose (LD50) was 2g/1kg of body weight. Evaluation of anti-inflammatory and anti-oxydant activity of the seeds of Silybum marianum L. [document électronique] / Niamat Allah Mili, Auteur ; Nour Elhouda Semcha, Auteur ; Karbab,Ahlem, Directeur de thèse . - Setif, Algerie : Faculté des sciences de la nature et de la vie, 2023 . - 41 Feuilles. ISSN : MS/1490 Langues : Français Catégories : Thèse et mémoire:Master:Immunologie Mots-clés : Silyum marianum  Antioxidants  Anti-inflammatory  toxicity  Anticoagulant. Résumé : The Silybum marianum is one of the most important plants used in traditional medicine. It is an herbaceous plant from the asteraceae family and originally grows in the Mediterranean region.Our study aims to evaluate the antioxidant and anti-inflammatory activities, as well as the toxicity and anticoagulant properties of Silybum marianum seeds. We employed two extraction methods (soaking and boiling) and conducted qualitative and quantitative chemical analyses of these extracts. Additionally, we assessed the antioxidant activity using the DPPH free radical scavenging assay and the anti-inflammatory activity (in vivo) using the ear edema model. Furthermore, we evaluated the toxicity and anticoagulant activity. The results showed that the ethanolic extract had a higher yield percentage of 3.71% compared to the aqueous extract. The chemical analysis of Silybum marianum seeds revealed significant amounts of polyphenols, flavonoids, free quinones, and tannins, while saponins were absent. Regarding the anti-inflammatory and antioxidant activities, the ethanolic extract exhibited values of 84.56% and an inhibitory concentration of 0.24 mg/mL, respectively. The extracts did not cause any changes in behavior or mortality of the treated animals. The calculated lethal dose (LD50) was 2g/1kg of body weight.

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
MS/1490	IMM/CD169	DVD et CD	Bibliothèque SNV	Français	Disponible

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