Design, green synthesis, molecular docking, computational analysis, intermolecular interactions energy, antiinflammatory and antioxidant effect of an α - hydroxyphosphonate. / Imene Boussouar / Sétif [Algérie] : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1 (2024) 

Public ISBD Titre : Design, green synthesis, molecular docking, computational analysis, intermolecular interactions energy, antiinflammatory and antioxidant effect of an α - hydroxyphosphonate. Type de document : document électronique Auteurs : Imene Boussouar, Auteur ; Nedjet Boudhane, Auteur ; Louiza Ouksel, Directeur de thèse Editeur : Sétif [Algérie] : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1 Année de publication : 2024 Importance : 62 Feuilles Format : PDF ISBN/ISSN/EAN : MS/1994 Langues : Anglais Catégories : Thèse et mémoire:Master:Biochimie appliquée Mots-clés : - α-hydroxyphosphonates  In silico, In vitro  MOE  ADMET  Antiinflammatory  Antioxidant. Résumé : This Work has been devoted to the synthesis of α-hydroxyphosphonates derivative by two methods: classical and microwave method the physicochemical characterization of this molecule was carried out by the chromatographic and spectroscopic methods (TLC, UV-vis, and IR).The anti- inflammatory effect of our molecule was evaluated in silico using a molecular docking of our molecule with JAK1 and JAK2 and in vitro was evaluated using the protein denaturation inhibition test. The antioxidant effect was evaluated in silico using a molecular docking of our molecule with PRDX5 and in vitro using a chemical method of DPPH radical scavenger (IC 50). Lipinski’s rules, absorbance and toxicity of our molecule were compared with two types of drugs. This study allowed it was concluded that the resulting compound has significant anti-inflammatory and antioxidant activity. En ligne : http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/5656/1/BAPP-CD220---- [...] Design, green synthesis, molecular docking, computational analysis, intermolecular interactions energy, antiinflammatory and antioxidant effect of an α - hydroxyphosphonate. [document électronique] / Imene Boussouar, Auteur ; Nedjet Boudhane, Auteur ; Louiza Ouksel, Directeur de thèse . - Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2024 . - 62 Feuilles ; PDF. ISSN : MS/1994 Langues : Anglais Catégories : Thèse et mémoire:Master:Biochimie appliquée Mots-clés : - α-hydroxyphosphonates  In silico, In vitro  MOE  ADMET  Antiinflammatory  Antioxidant. Résumé : This Work has been devoted to the synthesis of α-hydroxyphosphonates derivative by two methods: classical and microwave method the physicochemical characterization of this molecule was carried out by the chromatographic and spectroscopic methods (TLC, UV-vis, and IR).The anti- inflammatory effect of our molecule was evaluated in silico using a molecular docking of our molecule with JAK1 and JAK2 and in vitro was evaluated using the protein denaturation inhibition test. The antioxidant effect was evaluated in silico using a molecular docking of our molecule with PRDX5 and in vitro using a chemical method of DPPH radical scavenger (IC 50). Lipinski’s rules, absorbance and toxicity of our molecule were compared with two types of drugs. This study allowed it was concluded that the resulting compound has significant anti-inflammatory and antioxidant activity. En ligne : http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/5656/1/BAPP-CD220---- [...]

Exemplaires

Code-barres	Cote	Support	Localisation	Section	Disponibilité
MS/1994	BAPP/CD220	DVD et CD	Bibliothèque SNV	Englais	Disponible

---

page 1/1