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| Titre : | Comparative analysis of in vivo and in vitro biological activity of aqueous and ethanol extracts from Senecio perralderianus Coss and Senecio giganteus Desf. |
| Auteurs : | Hibet-errahmene Rekaibi, Auteur ; Manal Rezkallah, Auteur ; Walid Mamache, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Setif, Algerie : Faculté des sciences de la nature et de la vie, 2023 |
| ISBN/ISSN/EAN : | MS/1583 |
| Format : | 36 Feuilles / 30 cm. |
| Langues: | Français |
| Catégories : | |
| Mots-clés: | Senecio perralderianuscoss (Sp) ; Senecio giganteus (Sg) ; Antihemolytic ; Acute oral toxicity ; Analgesic ; Anti-inflammatory effect ; Antiulcer ; GSH ; MDA ; antifungal. |
| Résumé : |
This study investigated the anti-hemolytic, acute oral toxicity, analgesic, anti-inflammatory , antiulcer and antifungal properties of aqueous (Aq) and ethanol (Eth) extracts from Senecio perralderianus (Sp) and Senecio giganteus (Sg), which are endemic species in Algeria that belong to the Asteraceae family. Many species in this family have a long history in traditional medicinal use. The extraction yields were 29.96% for SgAq, 19.86% for SpAq, 11.55% for SgEth, and 7.16% for SpEth, with the aqueous extraction yielding higher amounts than the ethanolic extraction.In vitro studies were conducted to assess the anti-hemolytic activity of the extracts, measured by the HT50. At a concentration of 100 μg/mL, only 33.01 ± 11.39% of erythrocytes were hemolyzed for SpAq and 175.1 min for SpEth, while 197.22 min for SgEth and 167.63 min for SgAq were observed at a dose of 25 μg/mL. The tested extracts were found to be non-toxic and showed no analgesic effect. Additionally, the extracts exhibited anti-inflammatory effects, with percentage inhibition ranging from 32.87 ± 7.83% to 42.13 ± 6.03% for SpEth and SpAq, and from 56.94 ± 5.5% to 64.58 ± 8.870% for SgEth and SgAq. The extracts also demonstrated ulcerogenic activity after treating mice with ethanol/HCl, with a percentage of protection ranging from 70.55 ± 2.84% to 74.84 ± 1.21% for Sg and from 72.02 ± 1.28% to 73.01 ± 2.058% for Sp, in the order of ethanol and aqueous extracts. Treatment of mice with the extracts resulted in a significant increase (P < 0.05) in GSH and MDA. These findings highlight the remarkable antihemolytic, gastroprotective, and anti-inflammatory effects of the extracts, underscoring their potential as valuable sources of bioactive compounds for therapeutic applications. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/1583 | B.APP/CD155 | DVD et CD | Bibliothèque SNV | Français | Disponible |
