Catalogue de la bibliothèque de SNV
| Titre : | Assessment of some biological activities of the aqueous and ethanolic extract of the aerial part of Senecio perralderianus and Senecio giganteus |
| Auteurs : | Soulaf Kolli, Auteur ; Toufik Krim, Auteur ; Walid Mamache, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Setif, Algerie : Faculté des sciences de la nature et de la vie, 2023 |
| ISBN/ISSN/EAN : | MS/1585 |
| Format : | 28 Feuilles / 30 cm. |
| Langues: | Français |
| Catégories : | |
| Mots-clés: | Senecio perralderianus ; Senecio giganteus ; Anti-inflammatory ; Analgesic ; Gastric ulcer ; AAPH ; Anti-fungal ; Flavonoids ; Toxicity. |
| Résumé : |
Senecio perralderianus and Senecio giganteus are plants belonging to the Asteraceae family, obtained from Babor (Sétif) and Maghres mountain. The aerial parts were used to prepare decoction and ethanolic macerations (Sp Aq, Sp Eth, SG Aq, and Sg Eth). The daily observation of mice, following oral administration of 2000 or 5000 mg/kg of each extract, showed no signs of neurological or physical toxicity. The anti-inflammatory properties of the two plant extracts were evaluated using croton oil-induced ear edema. Sg Aq and Eth extracts showed inhibition comparable to indomethacin, with inhibition values of 52.25% and 70.63%, respectively. However, the Sp extracts didn’t exhibit any activity. The analgesic effect induced by acetic acid (1%) was observed with Sp Eth extract (100 mg/kg), which showed a significant decrease to 19.17 ± 8.78 contractions. Oral administration of HCl-Eth to mice resulted in gastric ulcer formation, all extracts at a dose of 200 mg/kg showed significant protection against gastric ulcers, ranging from 68.38% to 75.78%. Pretreatment of mice with the extracts significantly increased protein content and GSH levels, with a slight increase in SOD and CAT levels, while reducing in lipid peroxidation. In vitro, the anti-hemolytic activity of Sp aq and Eth extracts at a concentration of 25 μg/ml effectively protected erythrocytes against AAPH-induced hemolysis, with values of 150.9 ± 4.686 min and 143.9 ± 1.39 min, respectively. For the anti-fungal activity all plants extract showed a potent activity against all the fungal strains tested, except for the Sg Aq extract, which did not show any effect against Fusarium culuorum. The Sg Eth extract exhibited an effect similar to the control group. On the other hand, the Sp Eth extract showed the highest effect against all the fungal strains tested. These activities may be attributed to the presence of flavonoids, phenols compounds in these extracts. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/1585 | B.APP/CD157 | DVD et CD | Bibliothèque SNV | Français | Disponible |
