Catalogue de la bibliothèque de SNV
| Titre : | Phytochemical screening and pharmacological investigations of Centaurium erthraea L. |
| Auteurs : | Maroua Kharchi, Auteur ; Rayene Nini, Auteur ; Noureddine Charef, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Setif, Algerie : Faculté des sciences de la nature et de la vie, 2023 |
| ISBN/ISSN/EAN : | MS/1667 |
| Format : | 47 Feuilles |
| Langues: | Français |
| Catégories : | |
| Mots-clés: | Centaurium erythraea ; Ethnopharmacological study ; Polyphenols ; Antioxidant activity ; Anti-inflammatory activity ; Hypoglycemic activity. |
| Résumé : |
Centaurium erythraea (CE) is a medicinal plant known for its diverse effects in folk medicine The aim of this study is to evaluate some bioactivities of the plant. An ethnopharmacological study was conducted to highlight its traditional uses. A qualitative and a quantitative analysis were conducted to identify the chemical composition and to determine the total phenolics, total flavonoids, total condensed tannins contents in CE extracts. Moreover, the antioxidant, anti-inflammatory, anticoagulant and hypoglycemic activities were tested in addition to the acute toxicity. The ethnopharmacological study showed that CE has a variety of medicinal effects but it is unknown in our country. The qualitative analysis indicated a diversity in secondary metabolites which are phenolics, flavonoids, tannins, quinones, terpenes and alkaloids while the anthraquinone, coumarins and proteins were absent. For the quantitative analysis, we obtained high amounts in polyphenols, flavonoids and condensed tannins with highest values of 77.61 μg gallic acid equivalent; 19.17 μg quercetin equivalent and 81.70 μg catechin equivalent/ mg dry extract, respectively, for decoction extract (DecE). For the antioxidant activity, the DPPH radical scavenging assay showed IC50 = 119μg/ml and for the reducing power IC50 = 85.32 μg/ml for DecE. The anti-inflammatory activity showed a percentage of 86.11 %, for DecE. The results corroborated strong anticoagulant and hypoglycemic effects. CE was not toxic even at 2 g/kg body weight. As what our experience has elucidated, C. erythraea has diverse pharmacological activities which confirms the purposes of the plant in folk medicine. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/1667 | B.APP/CD183 | DVD et CD | Bibliothèque SNV | Français | Disponible |
