Catalogue de la bibliothèque de SNV
| Titre : | Anti-inflammatory, analgesic, anti-ulcer and anti-fungal activities of two Algerian endemic species |
| Auteurs : | Nassima Mekhlouf, Auteur ; Ahkam Mezaghcha, Auteur ; Walid Mamache, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Setif, Algerie : Faculté des sciences de la nature et de la vie, 2023 |
| ISBN/ISSN/EAN : | MS/1669 |
| Langues: | Français |
| Catégories : | |
| Mots-clés: | S.perralderianus ; S.giganteus ; Anti-inflammatory ; Analgesic effect ; AAPH. |
| Résumé : |
The plants Senecio perralderianus and Senecio giganteus belong to the family Asteraceae and are found exclusively in Algeria. The aerial parts of S. perralderianus and S. giganteus were extracted using ethanol and water to obtain the following extracts: Sp Aq, Sp Eth, Sg Aq, and Sg Eth. The Sp Eth demonstrated a strong analgesic effect by inhibiting acetic acid-induced abdominal contractions by 81.61%. In contrast, the extract of Sg did not show any analgesic effect. When applied topically at a dose of 2 mg/ear, the extracts of both S. perralderianus and S. giganteus displayed anti-inflammatory activity against croton oil-induced ear edema. Sg Aq and Sg Eth extracts exhibited inhibitions with values of 73.61 ± 8.78% and 68.05 ± 9.73%, respectively. Mice were orally fed with 200 mg/kg of the plant extracts being studied and then given HCl-ethanol. The extracts demonstrated a similar protective effect to omeprazole®, with a range of protection between 68.38% and 75.78%. Furthermore, pre-treatment with the extracts significantly increased protein content and levels of GSH, with slight increases in SOD and CAT levels. The extracts also reduced lipid peroxidation. The antioxidant activity of the plant extracts was confirmed invitro by their anti-hemolytic effect on erythrocytes against AAPH. Sp Aq demonstrated a similar effect to Trolox, with an HT50 value of 179.2 ± 5.46 min. The studied extracts also demonstrated a strong inhibition against the tested fungi. These activities could be attributed to the presence of flavonoids, phenols, and caffeic acid compounds in the extracts of the plants being studied. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/1669 | B.APP/CD185 | DVD et CD | Bibliothèque SNV | Français | Disponible |
