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| Titre : | Evaluation of antioxidant, anti-inflammatory and anti-coagulant activities of Portulaca oleracea L. |
| Auteurs : | Israa Merchedi, Auteur ; Karbab,Ahlem, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Sétif : Faculté des Sciences de la Nature et de la Vie, 2024 |
| ISBN/ISSN/EAN : | MS/1888 |
| Format : | 47 Feuilles |
| Langues: | Anglais |
| Catégories : | |
| Mots-clés: | Portulaca oleracea L. ; Antioxidant ; Anti-inflammatory ; Anticoagulant activities ; Secondary metabolites. |
| Résumé : |
Portulaca oleracea L., commonly known as "Redjla" and belonging to the Portulacaceae family, is a widely used food plant with both culinary and medicinal properties. This study aimed to investigate the antioxidant, anti-inflammatory, and anticoagulant effects of aqueous decoction derived from the seeds of this plant. The extract yield was determined to be 4.93%. The total polyphenol, flavonoid, and tannin contents of the decoctions were determined using spectrophotometric colorimetric methods. The analysis of this extract revealed the presence of secondary metabolites such as total polyphenols, estimated at 69.10 ± 2.43 mg EGA/gDE, flavonoids also present at 5.63 ± 0.37 mg EQ/gDE, and tannins, which are likely to express the desired activities. The antioxidant activity was assessed through the DPPH free radical scavenging technique, yielding an IC50 value of (0.116±0.02 mg/mL) demonstrated the extract's ability to trap radicals. The anti-inflammatory activity in vitro was evaluated at different concentrations (16 mg/mL, 8 mg/mL, and 4 mg/mL) using aspirin as reference drug. The results showed significant inhibition of inflammation at all concentrations tested. Furthermore, the anticoagulant activity of the aqueous extracts was evaluated by measuring the clotting time in seconds at different concentrations (4 mg/mL, 2 mg/mL, and 1 mg/mL). The results indicated prolonged clotting times, suggesting possible anticoagulant effects in the aqueous extracts. Overall, the study showed that aqueous extracts of Portulaca oleracea seeds exhibit antioxidant, anti-inflammatory and anticoagulant activities, which can be attributed to their high content of polyphenols, flavonoids and tannins. These results support the traditional use of Portulaca oleracea as a medicinal plant with potential health benefits. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/1888 | IMM/CD205 | DVD et CD | Bibliothèque SNV | Français | Disponible |
