Titre :	Flavonoids and it's anti-cancer activity
Type de document :	document électronique
Auteurs :	Rayene Yasmine Amirouche, Auteur ; Selsabil Amor, Auteur ; Hamama Bouriche, Directeur de thèse
Editeur :	Sétif [Algérie] : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1
Année de publication :	2024
Importance :	42 Feuilles
Format :	PDF
ISBN/ISSN/EAN :	MS/1996
Langues :	Anglais
Catégories :	Thèse et mémoire:Master:Biochimie appliquée
Mots-clés :	- Anticancer  Antioxidants  Biological activities  Flavonoids  Polyphenols.
Résumé :	Flavonoids are polyphenolic compounds found as integral components of the human diet. They are consisting of a 15-carbon basic skeleton (C6-C3-C6), composed of a chroman (C6-C) nucleus (the benzo ring A and the heterocyclic ring C), also with phenyl (the aromatic ring B) substitution usually at the 2-position. Different substitutions can typically occur in the rings, A and B. Based on the arrangement of the hydroxyl groups, the degree of unsaturation and the oxidation of the heterocyclic C-ring flavonoids, could be further classified into: flavones, flavonols, flavanones, flavanonols, flavanols, isoflavones, anthocyanidins, and chalcones. These secondary metabolites undergo metabolic transformations in the small intestine, liver and kidney. Flavonoids display a great diversity of biological activities such as antioxidants, anti-inflammatory and immunomodulatory, antiallergic, estrogenic activity,antimicrobial, antiviral, among others. Flavonoids have beneficial health effects and can be considered as chemopreventive or therapeutic agents against cancer. Several mechanisms might account for their potential anticancer actions. Indeed, they possess the propensity to modify or modulate the production of ROS, the activities of enzyme systems involved in cell signal transduction and other enzymes such as cytochrome P450, GST, quinone reductase, and UDP-GT. flavonoidscan also regulate cell cancer proliferation, differentiation apoptosis, tumorgrowth and metastasis.
En ligne :	http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/5666/1/BAPP-CD222---- [...]

Flavonoids and it's anti-cancer activity [document électronique] / Rayene Yasmine Amirouche, Auteur ; Selsabil Amor, Auteur ; Hamama Bouriche, Directeur de thèse . - Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2024 . - 42 Feuilles ; PDF.
ISSN : MS/1996
Langues : Anglais

Catégories :	Thèse et mémoire:Master:Biochimie appliquée
Mots-clés :	- Anticancer  Antioxidants  Biological activities  Flavonoids  Polyphenols.
Résumé :	Flavonoids are polyphenolic compounds found as integral components of the human diet. They are consisting of a 15-carbon basic skeleton (C6-C3-C6), composed of a chroman (C6-C) nucleus (the benzo ring A and the heterocyclic ring C), also with phenyl (the aromatic ring B) substitution usually at the 2-position. Different substitutions can typically occur in the rings, A and B. Based on the arrangement of the hydroxyl groups, the degree of unsaturation and the oxidation of the heterocyclic C-ring flavonoids, could be further classified into: flavones, flavonols, flavanones, flavanonols, flavanols, isoflavones, anthocyanidins, and chalcones. These secondary metabolites undergo metabolic transformations in the small intestine, liver and kidney. Flavonoids display a great diversity of biological activities such as antioxidants, anti-inflammatory and immunomodulatory, antiallergic, estrogenic activity,antimicrobial, antiviral, among others. Flavonoids have beneficial health effects and can be considered as chemopreventive or therapeutic agents against cancer. Several mechanisms might account for their potential anticancer actions. Indeed, they possess the propensity to modify or modulate the production of ROS, the activities of enzyme systems involved in cell signal transduction and other enzymes such as cytochrome P450, GST, quinone reductase, and UDP-GT. flavonoidscan also regulate cell cancer proliferation, differentiation apoptosis, tumorgrowth and metastasis.
En ligne :	http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/5666/1/BAPP-CD222---- [...]