Titre :	Evaluation of antioxidant and anti-inflammatory activities of Stipa tenacissima L decoction.
Type de document :	document électronique
Auteurs :	Bouthaina Djouada, Auteur ; Katia Hamam, Auteur ; Amel Bouaziz., Directeur de thèse
Editeur :	Sétif [Algérie] : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1
Année de publication :	2025
Importance :	44 Feuilles
ISBN/ISSN/EAN :	MS/2235
Langues :	Français
Catégories :	Thèse et mémoire:Master:Physiologie cellulaire et physiopathologie
Mots-clés :	Stipa tenacissima L  Decoction  Polyphenols  Inflammation  Oxidative stress  antioxidant activity  anti-inflammatory activity.
Résumé :	Stipa tenacissima L. is a medicinal plant traditionally used in Algeria to treat various health conditions, including weight loss, diabetes, and high blood pressure. In this study, secondary metabolites, antioxidant and anti-inflammatory activities of decoction extract of S. tenacissima were estimated. The aqueous extract was rich in polyphenols and flavonoids with values of 97,02 ± 0,56 mg GAE/g and 50.45 ± 1.65 mg QE/g respectively. Antioxidant activity was evaluated, as demonstrated by the hydrogen peroxide (H₂O₂) scavenging assay (IC50=0.571 ± 0.0252 mg/ml) and the ferric reducing power assay (IC50=0.261 ± 0.006 mg/ml). The anti inflammatory properties were evaluated both in vitro and in vivo. The in vitro egg albumin denaturation test showed an inhibition value of 79.2%, while the xylene-induced ear edema test recorded a reduction in inflammation 72.5% for 100 mg/kg. S. tenacissima was found to be rich in polyphenols and flavonoids and demonstrated effective antioxidant and anti-inflammatory activities across all tests. These findings support the traditional use of S. tenacissima in herbal medicine and suggest its potential as a safe natural remedy for conditions involving inflammation and oxidative stress.

Evaluation of antioxidant and anti-inflammatory activities of Stipa tenacissima L decoction. [document électronique] / Bouthaina Djouada, Auteur ; Katia Hamam, Auteur ; Amel Bouaziz., Directeur de thèse . - Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2025 . - 44 Feuilles.
ISSN : MS/2235
Langues : Français

Catégories :	Thèse et mémoire:Master:Physiologie cellulaire et physiopathologie
Mots-clés :	Stipa tenacissima L  Decoction  Polyphenols  Inflammation  Oxidative stress  antioxidant activity  anti-inflammatory activity.
Résumé :	Stipa tenacissima L. is a medicinal plant traditionally used in Algeria to treat various health conditions, including weight loss, diabetes, and high blood pressure. In this study, secondary metabolites, antioxidant and anti-inflammatory activities of decoction extract of S. tenacissima were estimated. The aqueous extract was rich in polyphenols and flavonoids with values of 97,02 ± 0,56 mg GAE/g and 50.45 ± 1.65 mg QE/g respectively. Antioxidant activity was evaluated, as demonstrated by the hydrogen peroxide (H₂O₂) scavenging assay (IC50=0.571 ± 0.0252 mg/ml) and the ferric reducing power assay (IC50=0.261 ± 0.006 mg/ml). The anti inflammatory properties were evaluated both in vitro and in vivo. The in vitro egg albumin denaturation test showed an inhibition value of 79.2%, while the xylene-induced ear edema test recorded a reduction in inflammation 72.5% for 100 mg/kg. S. tenacissima was found to be rich in polyphenols and flavonoids and demonstrated effective antioxidant and anti-inflammatory activities across all tests. These findings support the traditional use of S. tenacissima in herbal medicine and suggest its potential as a safe natural remedy for conditions involving inflammation and oxidative stress.