Catalogue de la bibliothèque de SNV
| Titre : | Xanthine oxidoreductase (XOR) : Structure and function. |
| Auteurs : | Diafi Afaf, Auteur ; Loubna Aggoun, Auteur ; Abderrahmane Baghiani, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2025 |
| ISBN/ISSN/EAN : | MS/2241 |
| Format : | 39 Feuilles |
| Langues: | Français |
| Catégories : | |
| Mots-clés: | Xanthine oxidoreductase ; Hypoxanthine ; Xanthine ; ROS ; NOS. |
| Résumé : |
Xanthine oxidoreductase (XOR) is part of a group of enzymes known as molybdenum iron-sulfur flavin hydroxylases. Animal XORs are homodimers with molecular mass of about 300 KDa. Each subunit contains a single peptide chain, which binds one molybdopterin cofactor (Mo-pt), two non-identical 2Fe-2S centers, and one FAS cofactor. It exists in two inter-convertible forms know as xanthine oxidase (XO, E.C. 1.17.3.2) and xanthine dehydrogenase (XDH, E.C. 1.17.1.4). XOR exists in two forms: active and inactive form, depending on the lack of Mo in the inactive form present in any XOR species. Its primary role is purine metabolism, where hypoxanthine is converted to xanthine and xanthine to uric acid, XOR is also active with many other substrates, things which classify XOR as an enzyme system. Additionally, XOR is involved in numerous physio pathological functions by its main production of ROS and NOS, which give the enzyme a great spread over in scientific research. The main physiological role of the enzyme is basically linked to signal transduction immune defense and lactation, whereas, in pathological role the enzyme is interfering in many diseases states, by the overproduction ROS or uric acid, leading to many physiological disorder such as ischemia reperfusion, gout and going through a large number of diseases from cancer to aging…...Also this study focus on the possibility of using a natural product as XOR inhibitors with less side effects. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/2241 | BAPP/CD261 | DVD et CD | Bibliothèque SNV | Englais | Disponible |
