Catalogue de la bibliothèque de SNV
| Titre : | Resveratrol, a Potent Antioxidant: In vitro and In vivo Insights |
| Auteurs : | Ghaniya Amor, Auteur ; Amina Meridja, Auteur ; Hanane Khither, Directeur de thèse |
| Type de document : | document électronique |
| Editeur : | Sétif (Algérie) : Faculté des sciences de la Nature et de la vie, Université Ferhat Abbas Sétif 1, 2025 |
| ISBN/ISSN/EAN : | MS/2293 |
| Format : | 49 Feuilles / PDF |
| Langues: | Français |
| Catégories : | |
| Mots-clés: | Antioxidant activity ; Free radicals ; In vitro ; In vivo ; Oxidative stress and resveratrol. |
| Résumé : |
Resveratrol, a naturally occurring polyphenolic compound, exhibits potent antioxidant properties and has attracted considerable interest within biomedical and pharmacological research. This theoretical review critically examines existing in vitro and in vivo evidence pertaining to the antioxidant efficacy of resveratrol. In in vitro assays, resveratrol demonstrated significant free radical scavenging activity, with IC₅₀ values ranging from 0.0257 to 32 μg/mL in the DPPH assay and 2.86 to 100 μg/mL in the ABTS assay, thereby indicating robust antioxidant potential. Reducing power assays further substantiated these findings, with FRAP EC₅₀ values spanning 3.05 to 700 μg/mL and CUPRAC values between 5.59 ± 0.07 and 120 μg/mL, confirming the compound’s capacity to reduce transition metals such as iron and copper. Additionally, resveratrol exhibited pronounced metal-chelating activity toward toxic metals—including iron, copper, arsenic, aluminum, and cadmium across both in vitro and in vivo models, contributing to the attenuation of metal-induced oxidative stress. In in vivo investigations conducted in rodent models, resveratrol demonstrated protective effects against oxidative stress-associated pathologies such as diabetic cataractogenesis (Type 1 Diabetes Mellitus), myocardial ischemia/reperfusion injury, cardiac dysfunction, age-related oxidative damage within the central nervous system, and cadmium-induced hepatotoxicity. Collectively, these data highlight the multifaceted antioxidant mechanisms of resveratrol and its potential therapeutic applications. However, further clinical studies are imperative to comprehensively assess its long-term efficacy, bioavailability, and safety in human populations. |
Exemplaires
| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
|---|---|---|---|---|---|
| MS/2293 | BAPP/CD279 | DVD et CD | Bibliothèque SNV | Englais | Disponible |
