| Titre : | An Introduction to Medicinal Chemistry |
| Auteurs : | Graham L. Patrick, Auteur |
| Type de document : | texte imprimé |
| Editeur : | Oxford : Oxford University Press, 2023 |
| ISBN/ISSN/EAN : | 978-0-19-886666-4 |
| Format : | 1 vol. (965 p.) / ill. en coul., couv. ill. / 28 cm |
| Note générale : | The market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources |
| Langues: | Anglais |
| Index. décimale : | 616.075 (Diagnostics et pronostics) |
| Catégories : | |
| Mots-clés: | Pharmaceutical chemistry |
| Résumé : |
Medication is widely used to support the human body to fight against infection and pain. In an era of pharmaceutical and medicinal challenges, we have all become more familiar with drug production and distribution. However, do we really know what happens before those drugs are distributed? What's the process behind drug discovery? How do our bodies interact with those chemicals? An Introduction to Medicinal Chemistry, 7th edition, offers a complete and accessible approach to this multidisciplinary field. Its student-friendly writing style makes this text an ideal tool for those coming to the subject for first time, but also for students looking to deepen their understanding. The book guides students through understanding the principles of drug action targets in Part A, to how drugs interact at a molecular level with our organs to offer therapeutic value in Part B, and exploring drug design and discovery, as well as regulatory procedures in Part C. Offering a practical approach, Part D provides a deeper look at specific tools and techniques of medicinal chemistry, concluding with emerging topics including antibodies and anticancer agents in Part E. From principles to practice, accompanied by examples and case studies emerging from current biomedical research, the book will equip students with a robust understanding of medicinal chemistry, to prepare them for future success. |
| Note de contenu : |
Sommaire - 1:Drugs and Drug Targets - 2:Protein Structure and Function - 3:Enzymes: Structure and Function - 4:Receptors: Structure and Function - 5:Receptors and Signal Transduction - 6:Nucleic Acids: Structure and Function - 7:Enzymes as Drug Targets - 8:Receptors as Drug Targets - 9:Nucleic Acids as Drug Targets - 10:Miscellaneous Drug Targets - 11:Pharmacokinetics and Related Topics - Case Study 1:Statins - 12:Drug Discovery: Finding a Lead - 13:Drug Design: Optimizing Target Interactions - 14:Drug Design: Optimizing Access to the Target - 15:Getting the Drug to Market - Case Study 2:The Design of ACE Inhibitors - Case Study 3:Artemisinin and Related Antimalarial Drugs - Case Study 4:The Design of Oxamni - Case Study 5:Fosfidomycin as an Antimalarial Agent - 16:Combinatorial and Parallel Synthesis - 17:In Silico Drug Design - 18:Quantitative Structure-Activity Relationships - Case Study 6: De Novo Design of a Thymidylate Synthase Inhibitor - 19:Antibacterial Agents - 20:Antiviral Agents - 21:Anticancer Agents - 22:Protein Kinase Inhibitors as Anticancer Agents - 23:Antibodies and Other Biologics - 24:Cholinergics, Anticholinergics, and Anticholinestarases - 25:Drugs Acting on the Adrenergic Nervous System - 26:The Opioid Analgesics - 27:Anti-Ulcer Agents - 28:Cardiovascular Drugs - Case Study 7:Steroidal Anti-Inflammatory Agents - Case Study 8:Design of a Novel Antidepressant - Case Study 9:The Design and Development Of Aliskiren - Case Study 10:Factor Xa Inhibitors - Case Study 11:Reversible Inhibitors of HCV NS-34A Protease |
| Côte titre : |
M4/12238-12239 |
Exemplaires (2)
| Cote | Support | Localisation | Disponibilité |
|---|---|---|---|
| M4/12238 | Livre | Bibliothèque centrale | Disponible |
| M4/12239 | Livre | Bibliothèque centrale | Disponible |
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