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Titre :
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In vitro and In vivo anti-inflammatory and hepatoprotector effects of Algerian Echium plantagineum and Brassica rapa extracts
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Auteurs :
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Soumia Benbrinis, Auteur ;
Abderrahmane Senator, Directeur de thèse
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Type de document :
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document électronique
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Editeur :
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Sétif : Université Ferhat Abbas faculté des sciences de la nature et de la vie département de Biochimie, 2023
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ISBN/ISSN/EAN :
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E-TH/2280
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Format :
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1 vol (107 f.) / ill.en coul.
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Note générale :
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Bibliogr. Annexes
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Langues:
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Anglais
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Catégories :
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Thèses (en français - en anglais) > Document électronique
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Mots-clés:
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Echium plantagineum
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Brassica rapa
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Résumé :
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This study aims to explore the phenolic composition of aqueous(Aq E)and methanolic(Met E)extracts of Algerian Echium plantagineum aerial part and evaluate their antioxidant capacity. Methods:Total phenolics, flavonoids and tannins contents were determined by spectrophotometric methods using Folin-Ciocalteu, aluminium chloride and hemoglobin precipitation assays,respectively.The antioxidant activities were evaluated using several in vitro tests including reactive oxygen species(ABTS.,OH.,O2.and H2O2)scavenging assays,ferrous ions chelating test, reducing power and anti-hemolytic assays.Results: The phytochemical study revealed a predominance of tannins, total polyphenols and flavonoids in both extracts.Aq E showed more efficiency to scavenge ABTS.,O2.and OH. radicals and to chelate ferrous ions. However,Met E was more efficient(IC50=193.87μg/mL)in scavenging H2O2 than Aq E (IC50 = 262.46μg/mL) . In the same way,Met E inhibited AAPH induced hemolysis(HT50=179.79±5.82 min)more than Aq E(HT50=161.62±5.87 min).On the other hand,both Met E and Aq E Exhibited very high reducing power (IC50= 117μg/mL and 128μg/mL, respectively). Conclusion: This study shows that Echium plantagineum extracts possess strong antioxidant activity,which is probably due to their phenolic composition.Therefore, this plant can constitute a promising source of natural antioxidants.
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Côte titre :
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E-TH/2280
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En ligne :
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http://dspace.univ-setif.dz:8888/jspui/bitstream/123456789/4292/1/Th%c3%a8se%20Benbrinis%20Soumia.pdf
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Exemplaires (1)
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| E-TH/2280 | Thèse | Bibliothèque centrale | Disponible |
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