| Titre : | Non-coding RNA transcripts in cancer therapy : pre-clinical and clinical implications |
| Auteurs : | Gautam Sethi, Auteur ; Milad Ashrafizadeh, Auteur |
| Type de document : | document électronique |
| Editeur : | New Jersey : World Scientific, 2023 |
| ISBN/ISSN/EAN : | 978-981-1267390-- |
| Format : | 1 vol. (377 p.) / ill., couv. ill. en coul |
| Note générale : | Bibliogr.Index |
| Langues: | Anglais |
| Index. décimale : | 616.99 (Tumeurs et diverses maladies transmissible ) |
| Catégories : | |
| Mots-clés: | Cancer Therapy MicroRNA LncRNA CircRNA |
| Résumé : |
Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications" provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described. |
| Note de contenu : |
Contents: • MicroRNAs (miRNAs) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets . • MicroRNAs (miRNAs) in Cancer Metastasis: Molecular Interactions and Possible Therapeutic Targets . • MicroRNAs (miRNAs) in Therapy Response of Human Cancers: Biological Aspects. • Exosomal miRNAs in Cancer Progression and Diagnosis . • Long Non-Coding RNAs (lncRNAs) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets. • Long Non-Coding RNAs (lncRNAs) in Cancer Metastasis: Molecular Interactions and Possible Therapeutic Targets . • Long Non-Coding RNAs (lncRNAs) in Cancer Therapy Response: Biological Aspects . • Exosomal Long Non-Coding RNAs (lncRNAs) in Cancer Progression and Diagnosis . • Circular RNAs (circRNAs) in Cancer Proliferation: Molecular Interactions and Possible Therapeutic Targets . • Circular RNAs (circRNAs) in Cancer Metastasis: Molecular Interactions and Possible Therapeutic Targets • Circular RNAs (CircRNAs) in Cancer Therapy Response. • Exosomal Circular RNAs (circRNAs) in Cancer Progression and Diagnosis. |
| Côte titre : |
EB/049 |
| En ligne : | https://www.worldscientific.com/doi/epdf/10.1142/13172 |
Exemplaires (1)
| Cote | Support | Localisation | Disponibilité |
|---|---|---|---|
| EB/049 | Livre | Bibliothèque centrale | Disponible |
Accueil
