| Titre : | Resolving the Cholesterol Controversy : The Scientists Who Proved the Lipid Hypothesis of Causation of Atherosclerosis and Coronary Heart Disease |
| Auteurs : | Gilbert R Thompson, Auteur |
| Type de document : | document électronique |
| Editeur : | New Jersey : World Scientific, 2023 |
| ISBN/ISSN/EAN : | 978-1-80061-399-7 |
| Format : | 1 vol. (248 p.) / ill. |
| Langues: | Anglais |
| Index. décimale : | 612 (Physiologie humaine) |
| Catégories : | |
| Mots-clés: | Cholesterol |
| Résumé : |
Resolving the Cholesterol Controversy recounts the science and scientific personalities behind the chain of discoveries upon which the lipid hypothesis of atherosclerosis was built.The narrative covers a period of just under 100 years, starting with Anitschkow's experiments with cholesterol-fed rabbits in 1913, and recounts the endeavours and achievements of the leading actors in this protracted scientific drama. The cast is drawn from an extraordinary variety of scientific disciplines: pathology, biophysics, epidemiology, nutrition, cardiology, lipidology, genetics, microbiology, pharmacology, and clinical trial design. Most of the scientists believed that cholesterol played a causal role in atherosclerosis and cardiovascular disease, but there were some who dissented strongly from this conclusion.The breadth of scientific disciplines involved in proving the lipid hypothesis is matched by the geographical spread of the participants. Anitschkow worked in Russia, Endo discovered the first statin in Japan, their commercial development by Merck took place in the USA and evidence of benefit from lowering cholesterol came from trials conducted in Scandinavia and the UK. The subsequent meta-analysis of these statin trials in 2005 proved the validity of the lipid hypothesis beyond any doubt. The history of how this all came about and its impact upon health policy and medical practice is recalled here in Resolving the Cholesterol Controversy. |
| Note de contenu : |
Contents: • Introduction to the Lipid Hypothesis: The Role of Cholesterol in Atherosclerosis • The Cholesterol-Fed Rabbit, an Animal Model of Atherosclerosis. • The Discovery that Cholesterol is Transported by Lipoproteins in the Blood and their Centrifugal Analysis. • The Framingham Study and Risk Factors for Coronary Heart Disease. • The Seven Countries Study and the Role of Dietary Fat in Determining Cholesterol Levels in Populations. • Pros and Cons of Lowering Cholesterol. • The Classification of Disorders of Lipoprotein Metabolism. • The Role of Sugar in Coronary Heart Disease. • Cardiological Opponents of the Lipid Hypothesis. • Familial Hypercholesterolaemia. • Discovery of the LDL Receptor. • The Role of Oxidised LDL in Atherosclerosis. • The Discovery of Lipoprotein (a). • Discovery of ApoE Polymorphism and Its Role in Lipid Metabolismm. • The Discovery of the First Statin. • The Development of Statins for Clinical Use. • The Statin Trials that Proved the Lipid Hypothesis. • Impact of the Lipid Hypothesis on the Science and Practice of Medicine. • The Future of Clinical Lipidology. |
| Côte titre : |
EB/062 |
| En ligne : | https://www.worldscientific.com/doi/epdf/10.1142/q0411 |
Exemplaires (1)
| Cote | Support | Localisation | Disponibilité |
|---|---|---|---|
| EB/062 | Livre | Bibliothèque centrale | Disponible |
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